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China Confirms Case of Bubonic PlagueHealth officials in China have confirmed a case of bubonic plague in a herdsman from the Inner Mongolia district, triggering increased prevention measures throughout the region.
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Twice-Yearly Lenacapavir May Change the World— If We Make It WorkEditor-in-Chief Jason Gallagher PharmD, FCCP, FIDP, FIDSA, BCPS discusses this agent as a potential tool for preexposure prophylaxis (PrEP) against HIV infection. And if it is approved, the ability to overcome access issues in low to middle income countries that have a greater need.
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Lower Respiratory Infections Linked with Influenza Lead to Substantial Global Health LossIn 2017, lower respiratory tract infections linked with influenza were responsible for an estimated 145,000 deaths worldwide.
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Current and Potential Treatment Options for Stenotrophomonas maltophilia InfectionsWe review current and emerging treatment options for infections caused by the difficult-to-treat, intrinsically multidrug-resistant organism Stenotrophomonas maltophilia.
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COVID-19: A PrimerThis virus has multiple facets and highlights a need for real-time learning.
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Intra-abdominal Infection With Eikenella corrodens in a Woman With Ovarian Cancer“A bite bug in the belly.”
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Examining An Emergence of Multi-drug Resistance Among Candida SpeciesDespite having emerged as either the third or fourth leading cause of blood stream infections in the United States, the threat of multi-drug resistant Candida species remains an underappreciated concern.
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What Can We Learn From Outbreaks of HIV and Zika?Parallels between the recent Zika epidemic in Brazil and the HIV pandemic in the 1980s, stress the importance of improving responses to public health crises.
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Sulbactam for Treatment of Carbapenem-Resistant Acinetobacter baumanniiThis is a challenging pathogen, requiring pharmacokinetic and pharmacodynamic considerations; the recent FDA approval of sulbactam-durlobactam offers new hope.
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Public Health Watch: “Rebound” COVID-19 Cases Following Paxlovid Treatment a “Scientific” But Not “Clinical” ConcernGovernment agencies and researchers continue to monitor the potentially troubling trend.
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Survey Finds US Hospitals Falling Short on Preventing C. Difficile InfectionA survey of 571 US hospitals regarding practices used to prevent Clostridium difficile infection indicates that nearly half of the facilities appear to not be taking steps to prevent the infection that kills nearly 30,000 people and sickens hundreds of thousands more each year, despite strong evidence that these steps work.
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Get Off the SOFA! Introducing the Quick Pitt Bacteremia ScoreThe quick Pitt Bacteremia Score offers accuracy comparable to the original version's across multiple infections, and maintains ease of use.
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A Case of CNS Nocardia farcinica Presenting as Aphasia in an Immunocompetent HostQuick recognition is key to early initiation of treatment and long-term survival.
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Mixed Fungal Brain AbscessClinicians review a patient case including diagnosis, treatment, and follow-up.
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Continuous Vancomycin Infusions Vs Intermittent Infusions Shows No BenefitThe area under the concentration-time curve (AUC) for vancomycin at discharge was the only modifiable factor found that was independently associated with patient safety outcomes.
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Multidrug-Resistant Pseudomonas aeruginosa Infections: Hard to Treat, But Hope on the Horizon?Two recently approved agents offer significant activity against these hard-to-treat conditions.
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Treatment Options to Address the Threat of Carbapenem-Resistant EnterobacteriaceaeNew agents are in development, but none represent a magic bullet for the problems that CRE infections present.
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ERADICATE: Ceftobiprole Noninferior to Daptomycin for Complicated Staphylococcus aureus BacteremiaThe phase 3 study met its primary and secondary end points of all-cause mortality, microbiological eradication rates, and new Staphylococcus aureus bacteremia complications.
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Multidrug-Resistant Pseudomonas aeruginosa Infections: Hard to Treat, But Hope on the Horizon?Two recently approved agents offer significant activity against these hard-to-treat conditions.
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Teaching Old Dogs New Tricks: Make the Most of Twitter to Boost ID Education, Engagement, and AdvocacyInfectious diseases clinicians turn to Twitter as a tool for education and collaboration.
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Synergy Between Antibiotics and The Innate Immune SystemGrowing evidence suggests that antimicrobials also interact with host innate immunity to provide potent indirect effects which enhance bacterial clearance and may result in more rapid and complete effects
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De-Escalation in Under 48 Hours Reduces 90-Day C difficile Infection Incidence 3-FoldA novel study from Seddon and colleagues adds to the body of evidence that supports what antimicrobial stewardship programs are so often challenged to do, early de-escalation.
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Using IL-6 Inhibitors to Treat COVID-19Use of an IL-6 inhibitor has the potential to prevent the cytokine storm caused by severe COVID-19 infection.
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Inappropriate Antimicrobial Use in the Emergency Department for Skin and Soft Tissue InfectionsStudies have shown high rates of inappropriate antibiotic prescribing and opportunity for improvement when it comes to ABSSSIs.
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A True Case Definition of Zika Virus Infection Should Still Be Pursued in Arbovirus Co-Transmission AreasDifferences in the clinical presentations of ZIKV infection which are occurring in different parts of the world might be an obstacle to setting a case definition that is good for use in all areas.
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New Initiatives for HIV Taking Off This YearAdvances in antiretroviral therapies increase opportunities for patients with HIV to have more successful treatment outcomes.
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Bacteriophage-Antibiotic Combinations: A Promising Alternative for Refractory Infections?Despite the initial abandonment of bacteriophages in most areas of the world, the era of antibiotic resistance has led to a resurgence of phage therapy in clinical practice.
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Bacteriophage-Antibiotic Combinations: A Promising Alternative for Refractory Infections?Despite the initial abandonment of bacteriophages in most areas of the world, the era of antibiotic resistance has led to a resurgence of phage therapy in clinical practice.
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Early Adjunctive Corticosteroids Do Not Improve Outcomes in HIV-Negative Adults With PcPThe clinical characteristics and outcomes of Pneumocystis jirovecii pneumonia differ in immunocompromised patients with and without HIV.
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Herpes Zoster Vaccine Subunit Prevents Herpes Zoster Episodes Following HSCTThe vaccine reduced the risk of herpes zoster by 68.2% in high-risk recipients of hematopoietic stem cell transplant.
