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Examining RSV Vaccines for SeniorsTwo RSV vaccines for seniors were FDA approved this year and here is an overview of the vaccines and the study data.
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Varicella Zoster Virus and Human Papillomavirus Vaccination in Immunocompromised PatientsVaccination for VZV and HPV requires special consideration in immunocompromised patients. They are at risk for more severe viral illnesses if not immune, but they may also have decreased response to, and increased adverse effects from, vaccines.
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Optimizing Vancomycin Therapy: A Review of AUC Calculation TechniquesThe ideal parameter for vancomycin monitoring is the area under the curve, which can be calculated using pharmacokinetic equations or Bayesian software.
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Antimicrobial Stewardship in the Era of Multidrug-Resistant InfectionsHere are some strategies to consider for optimal utilization.
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COVID-19 Impact on Antimicrobial Stewardship: Consequences and Silver LiningsThis crisis has united multidisciplinary groups and laid the foundation to better equip the health care workforce for future pandemics.
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Questions Linger Around COVID-19’s OriginA preview of our August 2021 issue Chairman’s Letter.
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Estimating the AUC for Vancomycin Using Non Trapezoidal EquationsIn the second part of our conversation, Abdulwhab Shremo Msdi, PharmD, discusses using this methodology.
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Phage, Combination Antibiotic Treatment For Resistant Pseudomonas aeruginosa InfectionErlinda Ulloa, MD, discusses a severe case including how they secured the phage treatment, and her experience with the investigational therapy.
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Ready, Set, Cabenuva: Implementing Cabotegravir/RilpivirineThis novel therapeutic option represents the first long-acting injectable approved for maintenance of HIV-1 suppression.
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PEN-FAST Forward: Accelerating Penicillin Allergy De-LabelingPEN-FAST is a validated risk stratification tool that promotes efficient, safe, and effective de-labeling of penicillin allergies.
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Safety of Cefazolin Has Been Underestimated for GBS Prophylaxis During LaborBoth undertreatment and overtreatment were common in this cohort of penicillin-allergic pregnant women with Group B Streptococcus (GBS).
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Humanizing Monoclonal Antibodies for Mucormycosis TreatmentAshraf S Ibrahim, PhD, details over 20 years of research on a spore coating protein and the development of VX-01 to block fungal tissue invasion.
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Gender-Affirming Care in Persons Living With HIVGender-affirming hormone therapy (GAHT) therapy consists of administration of exogenous hormones and suppression of endogenous hormone production, with the goal of obtaining characteristics more congruent with an individual’s gender identity. Here is a review of these therapies and consideration for PrEP and the risks associated with HIV in this diverse population.
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Trends in Carbapenemase-Producing Organisms: Prevalence, Treatment, and OutcomesA study of carbapenemase-producing organisms found similar rates of infections, highlighting treatment challenges, the role of rapid diagnostics, and surveillance on antimicrobial stewardship due to high mortality rates.
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Outpatient Antimicrobial Stewardship: The Keys to Developing a Successful ProgramThis form of stewardship can reduce unnecessary antibiotic prescribing, reduce costs, and optimize patient outcomes.
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Pharmacotherapy Options for COVID-19: Does Fluvoxamine Have a Place in Therapy?The need for safe and effective treatment against the various strains of COVID-19 increase, and investigators continue to assess various pharmacologic options.
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Infectious Diseases Provider Role in Extracorporeal Membrane Oxygenation InfectionsThere has been an emergence of extracorporeal membrane oxygenation-associated infections. Here is a review of how to define them and clinical management of this heterogeneous syndrome.
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Advancing Viral Disease Treatment of Recurrent Genital Herpes, Hepatitis B and D VirusesThe healthcare sector currently faces an unmet need in treating herpesviruses, hepatitis B, and hepatitis D, which could significantly improve patient outcomes. Addressing this involves considering the necessary steps and understanding the challenges pharmaceutical companies encounter as they work towards developing treatments for these conditions.
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Updates and Controversies in Necrotizing Soft Tissue InfectionsChanges in microbiology and antimicrobial resistance patterns warrant reevaluation of our current therapies for this condition.
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Gram-Negative Antibiotic Discovery Innovator Initiative to Drive Global Collaboration in Addressing AMR ChallengesKen Duncan, PhD, discussed the launch of a $50 million initiative focused on developing new drugs for critical pathogens contributing to antimicrobial resistance.
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CDC Influenza Surveillance Weekly ReportClinical and public health laboratories reported increased influenza virus detections over the past few weeks, but US cases remains comparatively low to previous flu seasons.
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Infection Control: AP Technology's Impact on Reducing HAIs and AMR PathogensDeborah Birx, MD, and Amy Carenza, BBA, highlight the targeting of multidrug-resistant organisms and tracking of infection trends without increasing staffing needs.
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The Importance of Local Health Departments in Combating HAIs and AMRNACCHO’s CEO Lori Tremmel Freeman discusses efforts and emphasizes the need for federal support and coordination.
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Linezolid Coadministration With Medications for Opioid Use Disorder: A Serotonin Toxicity Tightrope?This study characterized the incidence of serotonin syndrome and identified contributing risk factors with combined medications for opioid use disorder (MOUD) and linezolid use.
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Sorry Ganciclovir, You’re Just Not the One for MeImportant clinical considerations to know about resistant CMV infections.
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The Role of Pharmacists in the World of Pediatric Antimicrobial StewardshipThe limitation in the number of pediatric-specific guidelines by professional organizations, and results from large randomized clinical trials, may place an additional emphasis on literature evaluation skills for pediatric ASP pharmacists.
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The ART of Implementing an Antiretroviral Stewardship ProgramBy addressing ART-related medication errors and increasing linkage to care, antiretroviral stewardship programs can improve management of inpatients with HIV.
