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The Continued Search for Optimal Daptomycin Dosing Strategies in VRE Bloodstream InfectionsOptimal dosing of daptomycin is unknown, but study results suggest higher doses are required for successful clinical and microbiological outcomes.
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Investigational Phage Therapy Shows Positive Topline Results for Diabetic Foot OsteomyelitisClinical-stage company, BiomX, said its therapy, BX211, was found to be safe and efficacious for this infection that was associated with Staphylococcus aureus.
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Staying Ahead of the Curve: Implementing AUC-Guided Vancomycin DosingEvidence suggests AUC-guided vancomycin dosing is a safer method than traditional trough-guided dosing.
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NFID Urges Americans to Receive Influenza and Pneumococcal VaccinesThe NFID released data revealing that only 52% of adults in the United States plan to get vaccinated against the flu this season.
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Synergy Between Antibiotics and The Innate Immune SystemGrowing evidence suggests that antimicrobials also interact with host innate immunity to provide potent indirect effects which enhance bacterial clearance and may result in more rapid and complete effects
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Candida auris Is Changing the Paradigm of Antifungal-Resistant CandidaCandida auris is an emerging health care–associated multidrug-resistant fungal pathogen with public health concerns more similar to those of extensively drug-resistant bacterial pathogens than other species of Candida.
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Evaluating the Role of New Beta-Lactam Agents for Uncommon PathogensNovel β-lactam/β-lactamase inhibitor combinations and cefiderocol may play a part in the treatment of infections caused by Stenotrophomonas maltophilia, Achromobacter xylosoxidans, and Burkholderia cepacia complex.
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Echinocandin Dosing Considerations in Obese Patients: A ReviewObesity significantly impacts the pharmacokinetics (PK) of antifungal drugs like echinocandins, including volume of distribution (Vd) and clearance. However, despite these PK differences, current clinical evidence generally does not support the need for universal dose adjustments in obese patients. Clinicians should consider personalized dosing based on patient characteristics, infection severity, and specific drug properties due to echinocandins' favorable safety profiles.
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An NYC Nurse Journals Through the Worst Week of COVID-19A New York City nurse reflects on "peak-week" in a COVID unit.
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Email Reminders for Influenza Vaccine Uptake May Be Less Effective in Patients with DiabetesAnalysis of the NUDGE-FLU study reveals electronic nudges designed to boost influenza vaccination were more effective in older adults without diabetes, highlighting the need for tailored approaches in diabetes populations.
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A Pharmacist's Role in HIV Antiretroviral Stewardship in the HospitalPharmacists play vital roles in optimizing HIV treatment outcomes in multiple ways and in all medical settings.
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Study Shows Sulfonamide Antibacterials Capable of Reversing Azole Resistance in Candida albicansPreliminary studies provide convincing evidence for the synergistic use of sulfonamide agents with azole antifungals.
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CDC Recommends Update to Hepatitis C Virus ScreeningThe CDC made this recommendation after reviewing relevant literature, and noting that complete testing jumped from about only two-thirds of patients to nearly all patients.
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Final Diagnosis: Disseminated Kaposi Sarcoma With Tonsillar and Pulmonary InvolvementA shocking find on a CT scan leads to an unexpected diagnosis.
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Successful Stewardship Strategies in Long-Term Care FacilitiesOne successful model takes an engineering approach to patient safety outcomes focusing on work system improvements.
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PrEP: Estimating the Cost-Effectiveness Over 40 YearsShort-term investments in pre-exposure prophylaxis (PrEP) are predicted to result in long-term cost-savings and promote significant health benefits following its distribution in Germany, according to a new modelling study in Eurosurveillance.
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Emerging β-Lactamases in Pseudomonas aeruginosa That Threaten the Utility of New β-Lactam/β-Lactamase InhibitorsResistance against this pathogen with β-lactamase medications can vary according to geographic region.
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Long-Acting Anti-MRSA Agents: One Dose to Cure?A review of the current literature and future directions.
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Safety of Cefazolin Has Been Underestimated for GBS Prophylaxis During LaborBoth undertreatment and overtreatment were common in this cohort of penicillin-allergic pregnant women with Group B Streptococcus (GBS).
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A Closer Look at the Updated WHO HCV GuidelinesContagion™ Editorial Board member, Charitha Gowda, MD, MPH breaks down the World Health Organization hepatitis C (HCV) guidelines update, and reminds healthcare professionals to build on these guidelines to advocate for the most effective and safest treatment options for our individual patients and all patients worldwide.
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Evidence-Based Intervention Reduces C. diff Rates in Adults With CancerSMUCLA implements high-touch wipe down intervention to address the need for environmental disinfection of cancer patient care areas.
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Pharmacomicrobiomic Study Shows Significant Gut Bacteria Role in Drug Metabolism and ExposureA recent study provides what may be the first in-depth examination of the molecular mechanism of biotransformation of a large number of orally administered agents by the human gut microbiota.
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Salt, Ticks, and Lyme: A Case of Lyme Neuroborreliosis Presenting as SIADHThis case report is the fourth documented case of Lyme-induced syndrome of inappro­priate secretion of antidiuretic hormone (SIADH).
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COVID-19 or the Flu? Identifying Similarities and DifferencesKey signs and symptoms to help distinguish between the 2 respiratory illnesses.
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The Parallels Between Congenital Rubella Syndrome & Congenital Zika InfectionResearch presented at the 2017 Annual Pediatric Academic Societies (PAS) meeting examines the similarities between Congenital Rubella Syndrome and Congenital Zika Infection.
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Hospital-Acquired and Ventilator-Associated Pneumonia: Highlights and Pitfalls of the 2016 IDSA / ATS GuidelinesHospital-acquired and ventilator-associated pneumonia account for 22% of all hospital-acquired infections.
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Multidrug-Resistant Pseudomonas aeruginosa Infections: Hard to Treat, But Hope on the Horizon?Two recently approved agents offer significant activity against these hard-to-treat conditions.
