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2026 clinical practice guidelines developed by the IDSA and ESCMID address risk stratification, diagnosis and management of S aureus bacteremia.

Several combination products are currently in development for people with HIV. Here is a review of these treatments.

Despite competing national crises drawing attention elsewhere, experts warn that the ongoing H5N1 avian influenza outbreak in birds, cattle, and humans in the United States highlights critical gaps in surveillance, worker protections, and pandemic preparedness that must be addressed to prevent a future pandemic.

FDA's acting deputy commissioner for food said the US food supply remains safe even as CDC-confirmed cyclosporiasis cases climbed past 11,000, while a new survey found nearly half of Americans don't trust the agency to manage the outbreak.

Sharon Nachman, MD, chief of pediatric infectious disease at Stony Brook Children's Hospital, explains why local resistance data, not just global forecasts, should drive today's empiric antibiotic choices in children.

A global surveillance study of more than 100,000 pediatric bacterial isolates found rising antimicrobial resistance across all regions from 2004 to 2022, with forecasts projecting continued increases in resistance to last-line antibiotics through 2035.

A Rutgers Health study in Health Affairs found substantial growth in long-acting injectable buprenorphine prescriptions for opioid use disorder from 2021 to 2024, but with sharp state-level disparities driven by Medicaid policy differences, with fewer than 1% of buprenorphine prescribed as injectable in some states versus nearly 13% in others.

Shionogi's XOCOVA (ensitrelvir) is now available in the United States as the first oral option to help prevent COVID-19 after exposure, following phase 3 SCORPIO-PEP trial data showing a 67% reduction in symptomatic infection risk.

Three concurrent studies identify T cell exhaustion and Th2 skewing as distinct immune phenotypes in disseminated coccidioidomycosis, with targeted immunomodulation producing dramatic clinical responses in patients who had failed standard antifungal therapy.

As the Cyclospora outbreak continues, clinicians and public health advocates are highlighting a secondary risk: antibiotic treatment for the parasitic infection can disrupt the gut microbiome and raise the risk of C diff.

A study of 87 free-roaming New York City cats found 57.5% harbored at least 1 zoonotic endoparasite, with young male cats identified as Toxocara super-shedders depositing disproportionately high concentrations of roundworm eggs into urban soil.

A study in the American Journal of Physiology identifies retrotrapezoid nucleus (RTN) neurons as a critical and preserved circuit for counteracting opioid-induced respiratory depression, with optogenetic and chemogenetic stimulation of RTN neurons restoring breathing even during fentanyl administration.

Histoplasmosis is a widely distributed and often underdiagnosed fungal infection that can cause severe, sometimes fatal disease—especially in immunocompromised patients—due largely to persistent diagnostic delays and limited routine testing. Here is a review of diagnostics and treatment for the fungal infection.