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Echinocandin Dosing Considerations in Obese Patients: A ReviewObesity significantly impacts the pharmacokinetics (PK) of antifungal drugs like echinocandins, including volume of distribution (Vd) and clearance. However, despite these PK differences, current clinical evidence generally does not support the need for universal dose adjustments in obese patients. Clinicians should consider personalized dosing based on patient characteristics, infection severity, and specific drug properties due to echinocandins' favorable safety profiles.
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COVID-19 Impact on Antimicrobial Stewardship: Consequences and Silver LiningsThis crisis has united multidisciplinary groups and laid the foundation to better equip the health care workforce for future pandemics.
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Combination Hepatitis C Therapy Efficacious in Those With Previously Untreated Acute InfectionTreatment with glecaprevir/pibrentasvir (G/P) demonstrated a virologic response at post-treatment week 12, which was superior to the prior efficacy threshold.
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Starting an Inpatient Penicillin Skin Testing Service in 2023Patients with a penicillin allergy can be safely delabeled using minimal resources, opening up treatment options.
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INSPIRE Trials: Reducing Antibiotic Prescribing For Skin and Soft Tissue And Abdominal InfectionsLed by Shruti K. Gohil, MD, MPH, the trials examined how computerized physician order entry prompts can reduce the use of extended-spectrum antibiotics in hospitalized patients while maintaining patient safety.
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Infectious Diseases Provider Role in Extracorporeal Membrane Oxygenation InfectionsThere has been an emergence of extracorporeal membrane oxygenation-associated infections. Here is a review of how to define them and clinical management of this heterogeneous syndrome.
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All About the JUICE: Justifying Use of Non-Carbapenems for Infected NeCrotizing PancrEatitisManagement of this condition has been associated with antibiotic misuse. In the latest Bench to Bedside column, clinicians offer insights on therapy indications and what the latest literature reports on the condition.
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The Role of Rifampin in Bone and Joint InfectionsIn the latest column from the Society of Infectious Diseases Pharmacists (SIDP), here is a discussion on the use of rifampin as an adjunctive antibiotic treatment for patients with diabetic foot osteomyelitis.
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What You Need to Know About 3 Rare Infectious Eye DiseasesEric D. Donnenfeld, MD, discusses 3 uncommon yet highly infectious eye diseases, emphasizing the importance of timely treatment and preventative measures.
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What’s New With Non–COVID-19 VaccinesAlthough COVID-19 vaccination remains the primary focus for health care, other paramount vaccines need to be recognized. Here is a review.
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Fluoroquinolone Safe for Treating Severe Refractory M Pneumoniae PneumoniaInvestigators asked the children’s parents about the history of musculoskeletal-related disease, observed the children’s gait, and performed physical examinations.
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Barriers to Health Care Transition in Adolescents and Young Adults With Early Acquired HIV InfectionUnique challenges can affect the success of the shift from pediatric to adult care settings.
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Novavax Seeks Full FDA Approval for COVID-19 VaccineRobert Walker, MD discussed the company's application for full licensure and the importance of vaccination.
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Multidisciplinary Perspectives on HIV TreatmentA multidisciplinary panel concludes a discussion on best practices for managing patients with HIV in various healthcare settings and overcoming social health disparities.
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IDSA Makes Statement on HHS Changes to Vaccine Policy, Postponement of Vaccine MeetingTina Tan, MD, FIDSA, FPIDS, FAAP, Infectious Diseases Society of America (IDSA) president discusses the changes and offers a glimpse of what the US can expect in terms of limited access to new vaccines, increased incidence rates of disease, and new public health policy regarding immunizations.
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What We Know But Still Have to Learn About Long COVIDDespite advances in understanding and treating Long COVID, many questions about its mechanisms, susceptibility, and varied recovery patterns remain unresolved, underscoring the need for continued research.
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Resources Available for Patients with HIV Drug ResistanceThe panel concludes its discussion by talking about resources available for providers in managing their patients with HIV who experience drug resistance.
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Examining RSV Vaccines for SeniorsTwo RSV vaccines for seniors were FDA approved this year and here is an overview of the vaccines and the study data.
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Antimicrobial Stewardship: More Is BetterA robust stewardship program requires a comprehensive investment in technology and staff.
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IDSA Guidance on the Treatment of Antimicrobial Resistant Gram-Negative InfectionsSince late 2004, 7 novel antibiotics with activity against ESBL-E, CRE, and/or DTR P aeruginosa have been approved.
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Examining Disparities in HIV Mortality That Remain UnderexaminedSohaib Asghar, MBBS, MD, highlights the role of socio-economic factors and demographic disparities in HIV mortality from 1999 to 2023.
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Retinal Biomarkers Reveal Vascular Changes in Long COVIDManjot K Gill, MD, MS, FASRS, FRCS(C), discusses how reduced retinal capillary perfusion may provide insights into Long COVID’s neurological effects and potential treatment approaches.
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5 Strategies for Improving Sepsis Care ManagementHospitalists can be better equipped to identify patients most in need of intervention and standardize sepsis management efforts.
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Targeted Prophylaxis Reduces Hospital-Onset C difficile Infections in High-Risk PatientsThe STOP-CDI intervention presented by Matthew J.Ziegler, MD MSCE revealed using prophylactic enteral vancomycin, significantly reduced hospital-onset C difficile infections among immunocompromised patients.
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Climate Change Effects on Vector-Borne Disease: The Case of LymeWith evolving weather patterns, the natural habitat of ticks is expanding, and more people are becoming susceptible to them.
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Backpack Science: Enabling Realtime Work in the Field for Genomic Testing of Infectious DiseasesGathering data in the field, especially when it relates to infectious disease may have potentially profound implications for research because it enables scientists to generate valuable data quickly and efficiently without having to be in a laboratory setting.
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Stronger Than Yesterday: Decreased Hospital Readmissions After Strengthening of an OPAT ProgramAlthough close clinician monitoring is warranted to avoid complications for this this type of treatment, it can be beneficial to patients and help reduce care costs.
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Vancomycin AUC Implementation in Resource-Limited Settings and its Associated DifficultiesThe latest article from SIDP illustrates the challenges of area under the curve (AUC) implementation and offers insights for strategies and resources to overcome them.
