C. Difficile

Clostridium difficile infection leads to higher rates of overall mortality among patients with cirrhosis compared to those who do not, according to a new study.

Edmund A. Hooker, MD, DrPH, discussed the gaps in disinfection in the hospital and how hospital beds can be properly sanitized to prevent the spread healthcare-associatedted infections.

C diff and pneumonia still pose significant threats, according to the hospital survey.

Key considerations when choosing a treatment for gram-negative nosocomial infections include the patient’s referring facility.

A new report from the CDC shows substantial progress on the incidence of health care-associated infections in the United States, but there is still more work to be done.

Dale N Gerding, MD, provides insight about prevention options for C diff that are expected in the future.

In allogenic hematopoietic cell transplant patients, auto-FMT treatment led to the recovery of beneficial gut bacteria close to baseline levels within days.

Nimish Patel, PharmD, PhD, describes his study, which compared fidaxomicin with oral vancomycin in early targeted therapy of C diff.

Dale N. Gerding, MD, discusses bezlotoxumab and its use for preventing recurrent C diff infections.

Barbara Wells Trautner, MD, PhD, explains how overtreating asymptomatic bacteriuria can lead to antibiotic resistance or incorrect diagnoses.

A new study is the first to identify eosinophil counts as a predictor of outcomes in human patients.

New practical advice for the treatment of C difficile from SHEA advises against routine testing in NICU patients with diarrhea.

Nimish Patel, PharmD, PhD, discusses the updates to CDI management guidelines and the role of the pharmacists in providing education to physicians.

A new review examines previous studies and concludes that healthcare professionals could benefit from sensitivity training when dealing with patients who have HAIs.

Candidemia is a significant risk factor for C difficile infection in hospital patients.

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Fecal microbiota transplantation (FMT) is a widely accepted, safe, and effective treatment for recurrent Clostridium diffi­cile infection (rCDI), but does the cure endure?

Fidaxomicin and vancomycin are effective first-line therapies for Clostridium difficile, yet fidaxomicin may be more effective for achieving sustained symptomatic cure.

Dale N Gerding, MD, discusses the most recent changes to the guidelines of C difficile and the concerns of long-term effects of fecal microbiome transplants.

Alternative agents are often broader spectrum than ß-lactams, subjecting patients to collateral damage and subsequent selection for resistant organisms and Clostridium difficile.

The updated guidelines recommend targeting those with active infection and avoiding treatment of “carriers” of C difficile who are colonized but not symptomatic.

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Xingmin Sun, PhD, shares current progress on developing a vaccine for Clostridium difficile infection.

Xingmin Sun, PhD, discusses aspects that need to be considered before developing a vaccine for Clostridium difficile.

McGill University researchers find that infection with C difficile might more likely be linked to infected than colonized donors.

A new study suggests that for simple PCR-based detection of C. diff, dry rectal swabs were an effective substitute to the use of stool samples.

An economic evaluation finds that a bundled approach of stronger hand hygiene and improved environmental cleaning proved to be the best combination for reducing C. diff.

Dr. Thomas Sandora shares recent data on screening for asymptomatic carriage of Clostridium difficile and provides insight into what the preferred first-line treatment for the infection in children.

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Given the impressive efficacy of fecal microbiota transplantation (FMT) on decreasing recurrence of Clostridium difficile infection (CDI), the next logical step is seeing how it works for hospitalized patients with CDI.