C. Difficile

System hospitals are proactive in reducing incidence of C diff infections and CLABSIs, according to study in JAMA Network Open.

The new C diff strain may turn out to be particularly severe and requires sufficient monitoring.

Rebiotix has announced that it has completed enrollment of a phase 3 clinical trial for RBX2660.

Treatment with bezlotoxumab resulted in a statistically significant reduction of recurrent C diff in cancer patients, according to a new study.

Infection with C diff can increase hospital length of stay between 3 and 21 days, new research says.

A significant relationship exists between environmental exposures and colonization.

Some asymptomatic carriers of C diff went on to have clinical infection themselves within a 6-month period.

A team of investigators set out to identify whether a risk prediction model that was developed at Novant Health could accurately identify individuals at a high-risk for health care-associated C diff infection.

Prior to this study’s publication, the literature about pediatric C diff infection was limited.

The quick Pitt Bacteremia Score offers accuracy comparable to the original version's across multiple infections, and maintains ease of use.

Bezlotoxumab, a human monoclonal anti­body directed against Clostridioides diffi­cile toxin B, is currently indicated for the prevention of recurrent C diffi­cile infection

In 2017, a guideline update stripped metronidazole of its first-line therapy designation and crowned oral vancomycin as initial therapy for all C difficile infection cases.

DNA methyltransferase, an epigenetic process, has been found to mediate sporulation and pathogenesis in C diff.

The CDC’s plan calls for 30% reduction in C diff infections, but work remains to be done.

An observational study suggests that oral vancomycin may be associated with earlier symptom resolution than metronidazole for children hospitalized with non-severe C diff infections.

Agency’s annual report on healthcare-associated bugs highlights reduced incidence of CLABSI, CAUTI, and C diff.

Rates of health care facility-acquired C diff seemed to show improvement, but understanding community-acquired cases better in the future can help aid prevention efforts.

After receiving FMT capsules containing drug resistant ESBL E coli, 2 patients developed severe illness with 1 patient death.

Eravacycline may be an option for patients with a history of C diff or those with a history of infections who are at risk for developing the infection.

When guidelines are quickly implemented for C diff treatment recommendations, the changes are reflected quickly.

Use of high-risk antibiotics is linked to C diff infections, but the class of antibiotics with the strongest link has changed over time underscoring the need for ongoing assessment.

A hospital sheds light on how dogs can help identify C diff contamination.

Can UV disinfecting lights tackle health care-associated infections?

A new study using shotgun metagenomic sequencing found that FMT yielded a sustained decrease in antimicrobial resistance genes and potential pathogens in children with recurrent C diff.

Not all disinfectants are created equal and here's why we need to remember that.

A new study evaluates timelines for C diff treatment, diagnosis, and isolation.

Recent patient death calls into question viability of effective treatment for recurrent C diff.

This warning comes after the FDA was made aware of bacterial infections caused by multidrug-resistant organisms have occurred following transmission during FMT.

At MAD-ID 2019, Alison Lew, PharmD, spoke about her research on oral vancomycin prophylaxis to reduce CDI recurrence.

A study found that patients with complicated C diff infections were more likely to have been previously hospitalized with numerically less time between hospitalization and recent C diff episode.