Top Infectious Disease News of the Week—October 1, 2018
Stay up-to-date on the latest infectious disease news by checking out our top 5 articles of the week.
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Increasing Duration of Surgical Prophylaxis Does Not Decrease Odds of SSI
Instead, increasing duration of postoperative antimicrobial prophylaxis is associated with higher odds of acute kidney injury and C diff infection in a dose-dependent manner.
Off-label Use of Recently-Approved Antimicrobial Agents Is Common
Study results indicate that clinicians start prescribing new drugs off-label almost as soon as the drugs become available.
Incidence of Candidemia is Decreasing, But Not for Some Drug-Resistant Species
First large-scale study on trends in invasive candidiasis finds species distribution of isolates varied between blood and nonblood sterile sites.
Cardiac or Vascular Disease Not a Barrier to Delafloxacin For Treatment of Skin and Skin Structure Infections
Delafloxacin was found to be relatively safe and well tolerated in patients with acute bacterial skin and skin structure infections with past or present cardiac or vascular difficulties.
Analysis Underscores Substantial Burden of Candidemia in the United States
A new analysis details the substantial burden of candidemia in the United States and calls for ongoing surveillance efforts to help assess the impact of prevention interventions.
Severe Influenza May Be a Risk Factor for Aspergillosis
Over one-third of patients with invasive aspergillosis lacked a documented immunosuppressive condition.
Dr. George Thompson On Phase 2 STRIVE Study Evaluating Optimal Dosing for Rezafungin
George Thompson, MD, principal investigator of the STRIVE study discusses optimal dosing for rezafungin in treating candidemia and/or invasive candidiasis.
A Window Into the Outpatient UTI Antibiogram of New York
Researcher give insight into the importance of antibiograms in outpatient management of urinary tract infections
Patients with Carbapenem-Resistant Bloodstream Infections Less Likely to Survive Hospitalization
New research finds patients with carbapenem-resistant bloodstream infections have a lower likelihood of surviving hospitalization or being discharged home.
Progress in Fighting Ebola, Yet Resistance to Treatment in the DRC Remains
Mary Choi, MD, MPH, discusses the progress made in treating and preventing Ebola and the challenges of fighting the community resistance of the Congolese.
HIV-Positive Patients at Higher Risk of Late Mortality Following Cryptococcal Infection
Nonadherence to antiretroviral therapy was associated with a higher risk of death.
Infection Preventionists and Antimicrobial Stewardship Programs, A Marriage in Progress
A look into the challenges of including infection preventionists in antimicrobial stewardship programs.
Is “Non-Traditional” Risk Stacking the Solution for Pneumococcal Disease? Special ID Week 2018 Public Health Watch
The results of a new study suggest the approach can help stratify patients with the disease.
Contagion® to Report on ID Week 2018 in San Francisco, CA
The Contagion® editorial staff will be providing exclusive written and video coverage from ID Week 2018.
Are Prediction Risk Scores Matching up with Rapid Diagnostics?
Julie Ann Justo, PharmD, MS, BCPS-AQ ID, provides examples from her institution about using prediction scores and rapid diagnostic scores in concert.
Watch
Appropriate Treatment for Asymptomatic Bacteriuria
Barbara Wells Trautner, MD, PhD, explains the difference between asymptomatic bacteriuria and urinary tract infections.
Alternatives to Fluoroquinolones: Thinking Outside of the Box
Barbara Wells Trautner, MD, PhD, discusses finding alternatives to fluoroquinolones and facilitating patient communication to improve outcomes.
Choosing Appropriate Empiric Therapy Based on Susceptibility & Resistance Rates
Ellie J C Goldstein, MD, discusses how physicians need to rely on the data that is available when selecting an antibiotic.
Using A "Kick and Kill" Approach to Cure HIV
Investigators report results of the first randomized clinical trial to test a novel strategy to wake up and kill dormant HIV hiding in reservoir cells.
2-Drug HIV Regimen Comparable to 3-Drug Regimen in Treatment-Naïve Patients
Dolutegravir and lamivudine combination regimen met primary endpoint in 2 phase 3 studies of treatment-naïve patients with HIV.
Long-Term Immune Response Data for Investigational HIV Vaccine Revealed
Mosaic-based vaccine regimen maintained humoral and cellular HIV immune responses according to long-term data from APPROACH.
IAS-USA Releases 2018 Guidelines for HIV Treatment and Prevention
New guidelines on the prevention and treatment of HIV in adults from the IAS-USA Panel highlight advances made since the 2016 guidelines, as well as the need for new strategies.
Achieving Undetectable Viral Load On ART Renders Individuals Sexually Non-Infectious
PARTNER 2 study reports zero HIV transmissions over 8 years in gay couples who did not use condoms and had achieved an undetectable viral load on HIV treatment.
Struggles in Strengthening the Food Safety Chain
How are government agencies working to make food safer?
Biodefense World Summit Coverage—Biodetection Technologies
We're discussing presentations ranging from radiation biodosimetry to rapid viral testing
Improving Mass Casualty Management: the Role of Radiation Biodosimetry
How would you test patients for radiational exposure in a crisis?
Why Are Health Care Providers Using Fluoroquinolones Despite the FDA Warning?
Barbara Wells Trautner, MD, PhD, discusses why physicians are using fluoroquinolones despite the FDA’s warning.
The Risk of Aortic Dissection and Aneurysm in Patients Taking Oral Fluoroquinolones
Barbara Wells Trautner, MD, PhD, explains the risk of aortic dissection and aneurysm in patients taking oral fluoroquinolones.
New Research Reinforces Efficacy of Plazomicin
Research presented at the 2018 ASM Microbe Meeting has reinforced the value of the just-approved next-generation aminoglycoside antibiotic, plazomicin, in treating multidrug-resistant Enterobacteriaceae.