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Saye Khoo, MD, lead presenter of DOLPHIN-2, explains the details of the research on the differences between efavirenz regimen and dolutegravir when initatied during the third trimester of pregnancy.

A study reports that weight gain in individuals on ART was associated with lower BMI, reduced proportion of hypogonadism, increased proportion of psychiatric disorders, and non-PI-containing regimens.

A study characterizes the genotypic profile and the phenotypic susceptibility to temsavir in patients with multidrug resistant HIV who could be candidates for fostemsavir.

Investigators report 12-month outcomes from the Botswana Epidemiological ART Treatment Cohort Study (BEAT), an observational research cohort tracking virologic and clinical outcomes of people living with HIV who are beginning dolutegravir-based regimens.

Using EHR data, a study team identified 6076 potential PrEP candidates in a large health system, of whom 5577 (92%) were not on PrEP at the time.

PrEP use in persons with undetected HIV infections contributes to drug resistance and has investigators urging regular screening.

HIV incidence rates in MSM and transgender women taking F/TAF or F/TDF were found to be very low and significantly less than the rate in at-risk individuals not on PrEP in the US.

Paul Drain, MD, MPH, discusses the results of a study evaluating point-of-care viral load testing and discusses the advantages to implementation.

Following FDA approval of a single-tablet bictegravir, emtricitabine, and tenofovir alafenamide regimen for use in adults with HIV, investigators are exploring the safety and efficacy of the same therapy in children and adolescents aged 6 to 18 years.

Weight gain is often a concern for patients on ART. But what about the metabolic impact of PrEP on HIV-uninfected individuals?

DOLPHIN-2 reports that dolutegravir is well-tolerated and achieves more rapid virological suppression prior to delivery compared to efavirenz when initiated during pregnancy.

Bacterial sexually transmitted infections are still prevalent among men who have sex with men in England, but PrEP and other measures have sharply cut the rate of new HIV diagnoses.

A trial comparing raltegravir with efavirenz for antiretroviral therapy in treatment naïve pregnant women with HIV supports the use of raltegravir, especially for women starting ART later in gestation.

Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, has been fighting HIV/AIDS since the 1980s when the virus was first discovered. Now, thanks to a joint effort by multiple arms of the US Department of Health and Human Services, he’s making headway.

Investigators from England report the longest adult HIV remission observed since the Berlin patient.

Over a 12-month study, there was a 13.9% increase of retention with viral load suppression among participants who received rapid viral load results following point-of-care testing.

The Contagion® editorial staff will be providing exclusive written and video coverage from CROI 2019.

Investigators at Memorial Sloan Kettering Cancer Center determined valganciclovir was the preferred first-line preemptive therapy to prevent cytomegalovirus in patients following an allogeneic hematopoietic cell transplantation.

The length of mechanical friction applied to the needleless connector of a central venous catheter before insertion may make a difference in rate of disinfection.

A study conducted at the Salvador Zubirán National Institute of Health Sciences and Nutrition found that there were no cases of active tuberculosis detected in HSCT patients.

Investigators detected no relevant change in systemic concentrations of 9 probe drugs when rezafungin was dosed concomitantly.

A study reports that a respiratory virus infection diagnosis was not linked with a decrease in antibiotic exposure and use of respiratory viral panels did not affect clinical outcomes.

Following implementation of stewardship program-guided blood culture communication process, the time to optimal therapy was 9.2 hours shorter for patients at Saint Luke’s Hospital.

Antibiotic prescription following ventilation in children with RSV-LRTI was associated with a 1.21-day shorter duration of ventilation and a 2.07-day shorter length of hospital stay.

Hospital-onset sepsis is twice as deadly as community-onset sepsis and increases the risk of death 3-fold, according to the results of a cohort study comprising 2.3 million adult patients.

Emily Ricotta, PhD, ScM, highlights the increase in non-albicans candidiasis, which tends to be more antibiotic resistan,t in both bloodstream and sterile-site infections.

Melvin Weinstein MD, discusses the emerging technologies that will advance the field of blood culture testing.

Julie Ann Justo, PharmD, discusses the myths associated with penicillin allergies and why it is important to determine a patient's true penicillin allergy-status.

Kenneth Sherman, MD, discusses hepatitis B infections in immunocompromised patients and what clinicians should expect to see in the future for hepatitis B treatment.

Secondary analyses indicate that bezlotoxumab is more effective in reducing C diff recurrence in patients with pre-specified risk factors.