Gastrointestinal Infections

Additionally, its use is associated with colonization of the gastrointestinal tract by lower relative quantities of some potentially protective bacterial organisms.

The FDA has approved the antibiotic for the treatment of adult patients with travelers’ diarrhea caused by noninvasive strains of E coli not complicated by fever or blood in the stool.

Glenn Tillotson, PhD discusses the development of new antibiotics and therapies for C diff during an era when antibiotic resistance is a serious global health threat.

Edmund A. Hooker, MD, DrPH, discussed the gaps in disinfection in the hospital and how hospital beds can be properly sanitized to prevent the spread healthcare-associatedted infections.

Instead, increasing duration of postoperative antimicrobial prophylaxis is associated with higher odds of acute kidney injury and C diff infection in a dose-dependent manner.

Dale N Gerding, MD, provides insight about prevention options for C diff that are expected in the future.

In allogenic hematopoietic cell transplant patients, auto-FMT treatment led to the recovery of beneficial gut bacteria close to baseline levels within days.

Nimish Patel, PharmD, PhD, describes his study, which compared fidaxomicin with oral vancomycin in early targeted therapy of C diff.

Dale N. Gerding, MD, discusses bezlotoxumab and its use for preventing recurrent C diff infections.

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During a multidrug-resistant Campylobacter outbreak, 142 puppies were identified as receiving 1 or more antibiotic courses before arriving or while at the store.

The Ministry of Health and Child Care of Zimbabwe has declared a cholera outbreak after over 1,900 suspected cases have been reported.

Barbara Wells Trautner, MD, PhD, explains how overtreating asymptomatic bacteriuria can lead to antibiotic resistance or incorrect diagnoses.

A new study is the first to identify eosinophil counts as a predictor of outcomes in human patients.

The conventional approach to fighting resistant E coli infections typically involves the use of no more than 2 antibiotics; however, combining as many as 5 may be the trick to fighting these infections.

Investigators have found that a strain of E coli found in retail poultry products can cause a wide range of infections in people.

New practical advice for the treatment of C difficile from SHEA advises against routine testing in NICU patients with diarrhea.

Nimish Patel, PharmD, PhD, discusses the updates to CDI management guidelines and the role of the pharmacists in providing education to physicians.

A new review examines previous studies and concludes that healthcare professionals could benefit from sensitivity training when dealing with patients who have HAIs.

Candidemia is a significant risk factor for C difficile infection in hospital patients.

Barbara Wells Trautner, MD, PhD, discusses finding alternatives to fluoroquinolones and facilitating patient communication to improve outcomes.

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NIH researchers discovered that norovirus and rotavirus can be transmitted through cloaked viral clusters which exacerbate the spread and severity of disease.

Fecal microbiota transplantation (FMT) is a widely accepted, safe, and effective treatment for recurrent Clostridium diffi­cile infection (rCDI), but does the cure endure?

Fidaxomicin and vancomycin are effective first-line therapies for Clostridium difficile, yet fidaxomicin may be more effective for achieving sustained symptomatic cure.

Alternative agents are often broader spectrum than ß-lactams, subjecting patients to collateral damage and subsequent selection for resistant organisms and Clostridium difficile.

The updated guidelines recommend targeting those with active infection and avoiding treatment of “carriers” of C difficile who are colonized but not symptomatic.

The CDC and FDA are investigating a multistate outbreak of Cyclospora linked with vegetable trays produced by Del Monte Fresh Produce.

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Sixty-nine out of the 70 colistin-resistant isolates had either mcr-1 and/or mcr-3 genes.