Castellino is an associate professor of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Infectious Diseases and Geographic Medicine.
Rifaquizinone: A Novel Rifamycin-Quinolone Hybrid Antibiotic
April 28th 2025Rifaquizinone is a dual-pharmacophore antibiotic combining rifamycin and a fluoroquinolone-like compound, showing strong bactericidal activity against resistant Staphylococcus aureus strains and biofilms, with promising results for treating prosthetic joint infections (PJI) but limited oral bioavailability.
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