Imdusiran for Chronic Hepatitis B Achieves Functional Cure in 50% of Patients
November 18th 2024Arbutus CEO Michael McElhaugh discussed trial results showing that a combination of imdusiran, an RNAi therapeutic, and pegylated interferon alfa-2α can achieve a functional cure in chronic hepatitis B patients.
Echinocandin Dosing Considerations in Obese Patients: A Review
Published: November 18th 2024 | Updated: November 18th 2024Obesity significantly impacts the pharmacokinetics (PK) of antifungal drugs like echinocandins, including volume of distribution (Vd) and clearance. However, despite these PK differences, current clinical evidence generally does not support the need for universal dose adjustments in obese patients. Clinicians should consider personalized dosing based on patient characteristics, infection severity, and specific drug properties due to echinocandins' favorable safety profiles.
Due to FDA Policy Change, Fecal Microbiota Transplants Are in a Tenuous Position
November 13th 2024The country’s largest fecal distributor, OpenBiome, could be prevented from offering the product next year if the FDA does not approve the product used for fecal microbiota transplants to treat fulminant C difficile.