Mixing COVID-19 Vaccine Boosters Increases Immune Response
While receiving a booster of one’s original COVID-19 shot leads to an immune boost, this was heightened among individuals who received a different booster than their primary vaccine.
Predicting PrEP Use Based on PrEP Indications Among MSM
There are MSM who are indicated for PrEP use that don’t use it, and vice versa, the study authors found.
What Is the Ideal Duration of Daptomycin and Ceftaroline Combination Therapy for MRSA Bacteremia?
FDA Underwhelmed by Johnson & Johnson Appeal for Booster Shot Approval
The FDA suggested that Johnson & Johnson had not conducted an appropriately thorough test to prove its vaccine requires a six-month booster.
Concomitant COVID-19 and Influenza Vaccination Tested Against Twindemic
New clinical trial is first to describe concomitant administration of any vaccine with either an adenoviral vector or mRNA COVID-19 vaccine.
Role of Immunosuppression on Community-Acquired Clostridioides difficile Risk
CDI remains an urgent public health threat and continues to be the most frequent cause of diarrhea among hospitalized patients and overall hospital-acquired infection in the United States.
In Rural Areas, Injection Drug Users Have Less Knowledge, More Stigma About PrEP
People who inject drugs in rural areas had a less accurate understanding of HIV PrEP, largely due to stigma surrounding sexual orientation and drug use.
Probiotics Do Not Aid Prevention of Ventilator-Assisted Pneumonia
Investigators found no significant difference among hospitalized patients in the ICU being administered probiotics vs placebo.
Time to Prepare People to Accept COVID-19 Endemicity
Low HIV PrEP Awareness and Referrals among High-Risk Hispanic Populations
A recent study by the CDC found that HIV PrEP awareness and referrals are lower among Hispanic persons than non-Hispanic white persons.
AstraZeneca’s Long-Acting Antibody AZD7442 Reduced Risk of Severe or Fatal COVID-19
In the recent TACKLE phase 3 trial, AZD7442 significantly reduced the risk of developing severe COVID-19 or death, even among high-risk populations.
Monoclonal Antibodies Effective Against COVID-19 in Native American Patients
No ICU admissions or deaths were reported among Native American patients treated with monoclonal antibodies for COVID-19 in a recent study.
Influenza Virus Is Primed for Continual Emergence and Pandemic Potential
The broad host range and natural reassortment of the influenza virus has played an instrumental role in previous pandemics, and the virus is poised for future large-scale outbreaks.
Merck Files FDA EUA for Molnupiravir for COVID-19 Treatment
The filing is for the first oral antiviral therapy, and is based off its phase 3 trial.
HIV Self-Tests Boost Testing Among MSM
The TakeMeHome program, a public-private partnership to distribute HIV self-test home kits to at-risk populations, is reaching at-risk individuals who weren’t otherwise accessing testing.
Clinical Perspectives on Antimicrobial Stewardship
Providers offer their insights on this important topic.
FDA Advisory Committee Recommends Maribavir to Treat Cytomegalovirus CMV Infection and Disease
If the FDA approves maribavir, it will be the first and only treatment for adults with CMV as a result of a hematopoietic stem cell transplant or solid organ transplant.
C Difficile Bacteria Pervasive in Non-Healthcare Settings Worldwide, Found on 45% of Shoe Soles
A global study of C. difficile isolates worldwide found a very high prevalence of the bacteria on shoe soles.
New Technology Enables Differentiation of Bacterial and Viral Infections
It can help inform appropriate antibiotic prescribing, but likely would only form part of testing protocol, experts say.
Risk Score May Accurately Predict In-Hospital Mortality of HIV-Positive Patients
The HIV In-hospital Mortality Prediction (HIV-IMP) risk score showed good discrimination and calibration and may be useful in guiding clinical decision-making.
Though HIV Deaths are Decreasing, Women and Black Women Still Have Significantly Higher Mortality Rates
A recent study measured premature deaths among people with HIV by sex, race, and HIV risk factor.
Seniors Disproportionately Affected By Antibiotic-Resistant Infections
A new study shows Medicare-aged patients being treated in hospitals saw more of these types of infections, creating a greater burden on care and costs, and showing an increased mortality rate.
Pfizer-BioNTech Seek FDA EUA for Their COVID-19 Vaccine for 5-11 Year Olds
The companies made the request after their recent submission of data to support the emergency use authorization (EUA) in this patient population.
Waning of Pfizer-BioNTech Vaccine against COVID-19 Infection in Qatar
Qatar has the highest mRNA vaccine coverage in the world, but their vaccinated population is experiencing significant waning in vaccine efficacy, leading to breakthrough infections.
The WHO Officially Endorses the First Malaria Vaccine
Malaria has afflicted humanity for thousands of years, and the parasite is especially deadly for children and babies. The WHO has recommended the first malaria vaccine be deployed across sub-Saharan Africa.
Islatravir Subdermal Implant for HIV PrEP Has Promising Phase 1 Trial
This investigational therapy could be the first implantable form of PrEP.
AstraZeneca Files EUA for the First COVID-19 Antibody Prophylaxis
AstraZeneca’s long-acting antibody, AZD7442, would act as a supplement to vaccination and could provide up to a year of protection against symptomatic COVID-19.
Perceptions of and Willingness to Start PrEP among People Who Inject Drugs
People who inject drugs are at high-risk for HIV infection, but very few are interested in PrEP prescriptions.
The Importance of COVID-19 Booster Dosing for the Immunocompromised
US federal health agencies are recommending an additional shot for this diverse patient population, and here on some insights about vaccine efficacy and breakthrough infections in these groups.
Two Doses of Pfizer-BioNTech Vaccine Protect Against COVID-19 Hospitalizations for 6 Months
This study confirmed reports from the CDC and Israel Ministry of Health that found the Pfizer-BioNTech vaccine waned after 6 months.