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Pfizer’s COVID-19 pill Paxlovid, which includes nirmatrelvir and ritonavir, reduced the risk of hospitalization and death by 89% among adults at high risk for severe disease, recently published phase 2/3 trial data show.

The study authors suggest further research and investment to identify areas of support for individuals at the highest risk of poor outcomes.

The application is based on 2 Israeli studies for the additional shot for people 65 years and older.

In children and adolescents, the Pfizer-BioNTech vaccine was only mildly effective against symptomatic and asymptomatic COVID-19 infections. Broken down by variant, Omicron infections were more likely to occur and more likely to be asymptomatic.

Axcella Therapeutics chief medical officer Dr. Margaret Koziel discusses the stage 2a clinical trial for their novel long covid treatment.

This study comes just weeks after the company announced another HIV vaccine trial.

In a case series of 18 patients, all but 3 were cured by single-donor fecal microbiota transplantation capsule therapy.

The new COVID-19 sub-variant, called “Deltacron” or “Stealth Omicron,” appears to be the most contagious strain yet. However, this does not necessarily mean there will be a dramatic spike in cases.

In a nationally televised interview, Pfizer Albert Bourla said it is necessary to fend off waning protection.

Findings of JAMA Network Open analysis reveal effects of interventions designed to prevent spread.

The first study of COVID-19 vaccination status among romantic couples found 15.63% were in disagreement over whether to receive the vaccine.

“Deltacron,” a COVID-19 strain with genes from both the Delta and Omicron variants, appears to have been circulating since the beginning of the year.

The war on Ukraine is expected to drive COVID-19 and other infectious diseases, meaning health organizations and neighboring countries should prepare to assist in the impending health crises.

Popular pain and fever-reducing drugs can have unintended consequences when it comes to infectious diseases.

The retroviral HIV drug HERV-K could be effectively repurposed to treat patients with meningioma and acoustic neuroma, common primary brain tumors.

First-in-class triaminopyrimidine demonstrates antimalarial efficacy in first-in-human test of dosing, kinetics, and clearing parasite in infected volunteers.

Patients hospitalized during the COVID-29 pandemic for unrelated conditions were 20% more likely to die than in the prepandemic period.

The phase 3 results for its antibiotic, cefepime-taniborbactam, demonstrated it met its primary endpoint and the company says it is on track for a fourth quarter 2022 FDA NDA.

The product is designed to eliminate some of the drawbacks of fecal microbiota transplantation.

Using real-time genetic surveillance, investigators found bacterial infections rapidly develop resistance to antibiotics, only to have these gene mutations disappear within a few days of switching to a different treatment.

A large surveillance study of 2 symptom-reporting databases found side effects after Moderna or Pfizer-BioNTech COVID-19 vaccination were frequently nonserious and resolved within 1-2 days.

The company is examining its antiviral pill for children 6 to 17 years of age in combating COVID-19.

Study with Medicare beneficiaries found those at highest risk of severe COVID-19 among least likely to receive monoclonal antibody treatment.

There is no vaccine to prevent or treat chikungunya virus. Valneva announced 98.9% of phase 3 trial participants achieved CHIKV neutralizing antibodies after a signle dose of their vaccine candidate, VLA1553.

Even a mild COVID-19 infection can change the brain. People infected had a greater reduction in brain volume and performed worse on cognitive tests than those who did not contract COVID-19.

Investigators finding high risk for cardiovascular complications post-acute COVID-19 urge increased monitoring and preparedness.

Final analysis of phase 3, placebo-controlled trial confirms efficacy and safety of single-dose adenoviral vector vaccine against COVID-19.

“People don’t recognize that at least 1 in 5 of the deaths from opioids may result from endocarditis,” said National Institute of Drug Abuse (NIDA) director Dr. Nora Volkow, adding that endocarditis is “100% preventable.”

A new report based on samples from Texas and Kenya found significant proportions of samples from patients with CDI had nonsusceptible isolates.

Black Americans were more likely than White Americans to have a significant decrease in COVID-19 vaccine hesitancy over time.