Infectious Diseases and Transplantation—A Look Ahead
Taking a closer look at the infectious disease risks posed by transplantation and what the future might have in store as the scope of transplantation expands.
RESTORE-IMI 1 Trial Compares IMI/REL and IMI+CST in Patients with Bacterial Infections
Keith Kaye, MD, presented the analysis of the RESTORE-IMI 1 phase 3 trial which evaluated imipenem/cilastatin/relebactam versus imipenem/cilastatin plus colistin.
New Options in HIV Prophylaxis Gain Traction Based on Positive Trial Results—Public Health Watch
Three new trials, published in CID, highlight potential for intravaginal rings.
Entering a New Era of Blood Culture Testing Technology
Melvin Weinstein, MD, discusses the current and emerging technologies for the laboratory diagnosis of bloodstream infections.
Contamination Alone May Not Be to Blame for 2018 Spike in US Cyclosporiasis Cases
Following a significant spike in cases of cyclosporiasis, the CDC is investigating whether changes in diagnostic testing may be partially responsible for the rise in recent case counts.
Los Angeles Health Officials Investigate Typhus Outbreak
Los Angeles County Department of Public Health is investigating an influx of cases of flea-borne typhus in downtown Los Angeles.
Trends of Colonization and Clinical Cases of Candida Auris in the Chicago Area
Sarah Kemble, MD discusses trends identified from 33 point prevalence surveys that were performed across the Chicago area to identify colonization of Candida auris.
Multistate Listeria Monocytogenes Outbreak Linked to Ham Products
The CDC and USDA-FSIS are investigating an outbreak of Listeria monocytogenes infections linked to ready-to-eat deli ham products.
Neotrope Announces C Diff Foundation as a 2018 JL Simmons NonProfit PR Grant Recipient
Neotrope announced the C diff Foundation as a recipient of the JL Simmons NonProfit PR Grant.
Switch to D/C/F/TAF Results in Maintained High Virologic Suppression in Adults with HIV
Long-term safety and efficacy data from the pivotal phase 3 EMERALD trial were presented at ID Week 2018.
CRISPR Technology Could Help Thwart the Evolution of Antibiotic-Resistant Superbugs
Investigators from the University of Colorado Boulder have developed a strategy to fight antibiotic-resistant E coli using genetic disruption.
Phase 2 Trial Evaluates DAS181 for Parainfluenza Virus in Immunocompromised Patients
Roy Chemaly, MD, MPH discusses the findings of the phase 2 trial evaluating DAS181 for the treatment of parainfluenza virus lower respiratory tract infections in immunocompromised patients.
Treatment of Antibiotic-Resistant Infections: Back to the Future of Therapies
The stage may finally be set for the phage therapy era for recalcitrant bacterial infections.
Flu Vaccination Rates Among US Health care Workers Held Steady in 2017-2018 Season
A new report on influenza vaccination rates among US health care workers finds that employer requirements help keep vaccination rates of health care workers higher than that of the general public.
The Benefits of Dual Therapy for Gram-Negative Infections: An Assessment of the Guidelines
Julie Ann Justo, PharmD, MS, BCPS-AQ ID, shares takeaways from her presentation on combination therapy for gram-negative agents at the 2018 SIDP Annual Meeting.
OPAT-Antimicrobial Stewardship Team Coordination Ideal For Improving Patient Outcomes Upon Readmission
Efforts such as improved indication documentation and antimicrobial stewardship involvement may improve patient outcomes in some patients who are on outpatient parenteral antimicrobial therapy (OPAT) for ease of administration (EOA) that are readmitted to the hospital.
Antimicrobial Stewardship Processes Streamlined with Software
New software to facilitate prior authorization helped streamline the approval process and increase antimicrobial use tracking at the Hospital of the University of Pennsylvania.
Treatment Options for Immunocompromised Patients with Hepatitis B
Kenneth Sherman, MD, discusses current trends in the treatment of hepatitis B in immunocompromised patients and highlights research exploring treatment options for patients coinfected with HIV.
Letermovir Found to Reduce Clinically Significant CMV infection in HCT Patients
Letermovir found to prevent clinically significant CMV infection in HCT patients with CMV DNA when compared to placebo in recent phase 3 trial.
Ceftolozane/Tazobactam: Real-World Treatment Patterns & Associated Outcomes
A retrospective study evaluates ceftolozane/tazobactam in a large database of US hospitals to determine real-world patterns and outcomes associated with the treatment.
Adding Fosfomycin to Daptomycin Could Improve Outcomes of MRSA Bacteremia
The combination of daptomycin plus fosfomycin was more effective than daptomycin alone for treating patients with MRSA bacteremia.
Study Provides Real-World Support for Single-Dose Oritavancin For ABSSSIs
Results indicate patients who received single-dose oritavancin were significantly less likely to be hospitalized, compared to those who received multidose vancomycin.
Recalls You Should Be Aware Of—Week of September 30, 2018
We’ve rounded up a list of important US Food and Drug Administration (FDA) and US Department of Agriculture (USDA) recalls from this past week.
Top Infectious Disease News of the Week—October 1, 2018
Stay up-to-date on the latest infectious disease news by checking out our top 5 articles of the week.
FDA Approves Expanded Use of HPV Vaccine to Older Populations
The recombinant 9-valent human papillomavirus (HPV) vaccine, Gardasil 9 is now approved in adults 27 to 45 years of age.
Increasing Duration of Surgical Prophylaxis Does Not Decrease Odds of SSI
Instead, increasing duration of postoperative antimicrobial prophylaxis is associated with higher odds of acute kidney injury and C diff infection in a dose-dependent manner.
Off-label Use of Recently-Approved Antimicrobial Agents Is Common
Study results indicate that clinicians start prescribing new drugs off-label almost as soon as the drugs become available.
Accelerated Vaccine Dosing Schedule Approved for Japanese Encephalitis
The new vaccine schedule is 7 days between doses for adults aged 18 to 65, instead of the standard 28 days.
Incidence of Candidemia is Decreasing, But Not for Some Drug-Resistant Species
First large-scale study on trends in invasive candidiasis finds species distribution of isolates varied between blood and nonblood sterile sites.
Cardiac or Vascular Disease Not a Barrier to Delafloxacin For Treatment of Skin and Skin Structure Infections
Delafloxacin was found to be relatively safe and well tolerated in patients with acute bacterial skin and skin structure infections with past or present cardiac or vascular difficulties.